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News

Sep 17, 2019
Category: General
Posted by: jettebang

Info on Friday morning 

Sep 4, 2019
Category: General
Posted by: jettebang

New deadline for registration and submission of abstract is September 13th at 12 a.m.

Sep 4, 2019
Category: General
Posted by: jettebang

A beautiful morning run

Feb 5, 2019
Category: General
Posted by: jettebang

We are happy to announce that registration for First Scandinavian Baltic Pancreas Symposium, 20-21 September 2019, opens at the end of February on www.OPAC.nu

Oct 18, 2018
Category: General
Posted by: jettebang

The program for First Scandinavia Baltic Pancreas Symposium, September 2019 is now available on our website www.opac.nu


Publications

 Peer reviewed articles:

  1. Nielsen MFB, Mortensen MB, Detlefsen S. Identification of markers for quiescent pancreatic stellate cells in the normal human pancreas. Histochem Cell Biol. 2017;148(4):359-80. 

  2. Detlefsen S. IgG4-related disease: Microscopic diagnosis and differential diagnosis [in German]. Pathologe 2019 Nov;40(6):619-626

  3. Detlefsen S, de Vos JD, Tanassi JT, Heegaard NHH, Fristrup CW, Schaffalitzky de Muckadell OB. Value of anti-PBP, anti-CA-II, IgG4 and other serological markers for the differentiation of autoimmune pancreatitis and pancreatic cancer. Medicine (Baltimore), 2018; Aug;97(31):e11641. doi: 10.1097/MD.0000000000011641

  4. Detlefsen S. Synchronous pancreatic serous cystic neoplasm and duodenal neuroendocrine tumor: case report and review of the literature. Madelung AB

  5. Graversen M, Detlefsen S, Bjerregaard JK, Pfeiffer P, Mortensen MB. Peritoneal metastasis from pancreatic cancer treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Clin Exp Metastasis. 2017 May 17. doi: 10.1007/s10585-017-9849-7

  6. Larsen MH, Fristrup CW, Detlefsen S and Mortensen MB. Prospective evaluation of EUS-guided fine needle biopsy in pancreatic mass lesions. Endoscopy International Open 2018; 6(2):E242-8. 

  7. Huang L, Jansen L, Balavarca Y, Molina-Montes E, Babaei M, van der Geest L, Lemmens V, Van Eycken L, De Schutter H, Johannesen TB, Fristrup CW, Mortensen MB, Primic-Ċ½akelj M, Zadnik V, Becker N, Hackert T, Mägi M, Cassetti T, Sassatelli R, Grützmann R, Merkel S, Gonçalves AF, Bento MJ, Hegyi P, Lakatos G, Szentesi A, Moreau M, van de Velde T, Broeks A, Sant M, Minicozzi P, Mazzaferro V, Real FX, Carrato A, Molero X, Besselink MG, Malats N, Büchler MW, Schrotz-King P, Brenner H. Gut.Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations. 2017 Nov 20. pii: gutjnl-2017-314828. doi: 10.1136/

  8. Graversen M, Detlefsen S, Bjerregaard JK, Fristrup C, Pferiffer P, Mortensen MB. Prospective, single-center implementation and response evaluation of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for peritoneal metastasis. Therapeutic Advances in Medical Oncology 2018 /DOI: 10.1177/1758835918777036

  9. Bjerring OS, Hess S, Fristrup CW, Høilund-Carlsen PF, Mortensen MB. The impact of endoscopic ultrasound-guided fine-needle aspiration of lymph nodes on subsequent positron emission tomography/computed tomography imaging: a prospective study. Endoscopy 2019;51(02): 165-8.

  10. Christiansen CD, Petersen H, Nielsen AL, Detlefsen S, Brusgaard K, Rasmussen L, Melikyan M, Ekström K, Globa E, Rasmussen AH, Hovendal C, Christesen HT. 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT scans as diagnostic tools in focal congenital hyperinsulinism: a blinded evaluation. Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):250-261.

  11. Van der Steen I, van Albada ME, Mohnike K, Christesen HT, Stuart AJ, van der Linde A, Banerjee I, Boot AM. A Multicentre Experience with Long-Acting Somatostatin Analogues in Patients with Congenital Hyperinsulinism. Horm Res 2018;89(2):82-89. 

  12. Bendix J, Laursen MØ, Mortensen MB, Melikian M, Globa E, Detlefsen S, Rasmussen L, Brusgaard K, Christesen HT. Intraoperative ultrasound: A tool to support tissue-sparing curative pancreatic resection in focal hyperinsulinism. Frontiers Endocrinol, E-pub 22/8 2018, https://doi.org/10.3389/fendo.2018.00478  

  13. Nielsen MFB, Mortensen MB, Detlefsen S. Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations. World J Gastroenterol. 2018 Nov 7;24(41):4663-4678.

  14. Graversen M, Lundell L, Fristrup C, Pfeiffer P, Mortensen MB. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) as an outpatient procedure. Pleura and Peritoneum 2018;3(4): 20180128.

  15. Solass W, Sempoux C, Carr NJ, Bibeau F, Neureiter D, Jäger T, Di Caterino T, Brunel C, Klieser E, Fristrup C, Mortensen MB, Detlefsen S. Reproducibility of the Peritoneal Regression Grading Score (PRGS) for assessment of response to therapy in peritoneal metastasis. Histopathology 2019 Jun;74(7):1014-1024

  16. Kirkegård J, Aahlin EK, Al-Saiddi M, Bratlie SO, Coolsen M, de Haas RJ, den Dulk M, Fristrup CW, E.M. Harrison, M.B. Mortensen, M.W. Nijkamp, J. Persson, J.A. Søreide, S.J. Wigmore, T. Wik, F.V. Mortensen MB. Multicentre Study of Multidisciplinary Team Assessment of Pancreatic Cancer Resectability and Treatment Allocation. Br J Surg 2019; https://doi.org/1.1002/bjs.11093

  17. Christesen HT, Christensen L, Löfgren Å, Brøndum-Nielsen K, Svensson J, Brusgaard K, Samuelsson S, Elfving M, Jonson T, Grønskov K, Rasmussen L, Backman T, Hansen LK, Larsen AR, Petersen H, Detlefsen. Tissue variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromic congenital hyperinsulinism. Eur J Med Genet. 2019 Feb 20. pii: S1769-7212(18)30932-7 [E-pub ahead of print]

  18. Rasmussen LS, Vittrup B, Ladekarl M, Pfeiffer P, Mortensen MFV, Sall M, Detlefsen S, Bøgsted M, Fristrup CW. The effect of postoperative gemcitabine on overall survival in patients with resected pancreatic cancer: A nationwide population-based Danish register study. ACTA ONCOLOGICA 2019, doi.org/10.1080/0284186X.2019.1581374

  19. Bjerring OS, Fristrup CW, Pfeiffer P, Lundell L, Mortensen MB. The added value of endosonography and PET/CT to the traditional follow up strategy in patients radically resected for cancer either of the gastro-esophageal junction (GEJ), stomach or pancreas – EUFURO - a phase 2 randomized clinical trial. Br J Surg 2019 (in press)

  20. Kirkegård J, Mortensen FV, Hansen CP, Mortensen MB, Sall M, Engberg H, Fristrup CW. Waiting time to surgery for pancreatic cancer does not affect survival: A nationwide population-based cohort study. EJSO 2019 (in press).

  21. Harthimmer MR, Stolborg U, Pfeiffer P, Mortensen MB, Fristrup C, Detlefsen S. Mutational profiling and immunohistochemical analysis of a surgical series of ampullary carcinomas. J Clin Pathol 2019 Nov;72(11):762-770

  22. Knudsen KN, Mortensen MB, Detlefsen S. Squamous cell carcinoma of the common bile duct: A case report with genomic profiling. Pathol Int, Epub ahead of print

  23. Christesen HT, Christensen LG, Löfgren AM, Brøndum-Nielsen K, Svensson J, Brusgaard K, Samuelsson S, Elfving M, Jonson T, Grønskov K, Rasmussen L, Backman T, Hansen LK, Larsen AR, Petersen H, Detlefsen S. Tissue Variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromal congenital hyperinsulinism. Eur J Med Genet 2019 Feb 20. Pii: S1769-7212(18)30932-7 doi: 10.1016/j.ejmg2019.02.004. Epub ahead of print

  24. Thinesen MT, Schaffalitzky de Muckadell OB, Detlefsen S. IgG4 related sclerosing cholangitis involving intrahepatic bile ducts diagnosed with liver biopsy. Case Reports in Pathology 2018, article 2309203

  25. Detlefsen S, de Vos JD. Value of antiplasminogen binding peptide, anticorbon anhydrase, innunoglobulin G4, and other serological markers in the differentiation of autoimmune pancreatitis and pancreatic cancer, Tanassi J, et at. Medicine 2018:97(31):article 11641.

 

Other articles:

  1. Graversen M, Mortensen MB. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): A new treatment modality in patients with peritoneal metastases from pancreatic cancer. Pancreatic cancer, Nordic Newsletter, no. 4, 2017. (Invited publication) 

Oral Presentations:

  1. Graversen M, Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) som palliativ behandling ved pancreascancer med peritoneal karcinose. Dansk Pancreas Forum 2017, København

  2. Graversen M, Peritoneal metastases from pancreatic cancer treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Scandinavian HPB meeting, Lund, Sverige 2017.

  3. Christesen H. Hyperinsulinisme hos børn. Annual meeting, the Danish Society of Radiology, the Danish Society of Clinical Physiology and Nuclear Medicine, The Danish Society of Ultrasound and Radiographer, 25/1 2018, Odense.

  4. Christesen H. Diagnostic performance of 18F-DOPA PET/CT and 68GA-DOTANOC PET/CT scan on focal vs. non-focal type of congential hyperinsulinism. Congenital Hyperinsulinism Symposia, Children’s Hospital of Philadelphia, 14/4 2016

  5. Melikyan M, Makarov S, Gurevich S, Sokolov Y, Christesen H. Pancreatic insulinomas in childhood: clinical, morphological and genetic characteristics of 16 children. 10th International Meeting of Pediatric Endocrinology, Washington D.C., US, 14-17/9 2017 

  6. Christesen H, Congenital Hyperinsulinism. Etiology, pathophysiology, clinical presentation and therapy. Symposium: Team approach in the medical care for children and adults with hyperinsulinism. Christesen H. Almazov National Medical research Centre, St. Petersburg, Russia, March 5, 20181   

  7. Detlefsen S, Histopathology in Congenital Hyperinsulinism. Symposium: Team approach in the medical care for children and adults with hyperinsulinism. Almazov National Medical research Centre, St. Petersburg, Russia, March 5, 20181  

  8. Brusgaard K, Exome sequencing in patients with early childhood-diabetes or hyperinsulinemic hypoglycemia reveals novel genetic causes. 61. Deutscher Kongress für Endokrinologie, 14.03.2018 – 16.03.2018 · Bonn.  

  9. Graversen, M, The PIPAC Procedure. Peritoneal Metastazlarin Tedavisinde Basincli Intraperitoneal Aerosol Kemoterapi (PIPAC). Konferansimiza Davetlisiniz. (PIPAC Meeting at Anadolu Hospital Centre, Istanbul, Turkey.) 

  10. Graversen, M, Publications and the Danish Experience. Peritoneal Metastazlarin Tedavisinde Basincli Intraperitoneal Aerosol Kemoterapi (PIPAC). Konferansimiza Davetlisiniz. (PIPAC Meeting at Anadolu Hospital Centre, Istanbul, Turkey.) 

  11. Jørgensen MT, Mortensen MB., Clinical dillemmas in chronic pancreatitis. Dansk Pancreas Forum 2018 Meeting. Copenhagen 16.03.18 

  12. Hedegaard Jensen, G., Mortensen, M. B., Detlefsen, S., Value of the immunohistochemical panel IMP3, pVHL, maspin, S100P and Ki67 for the differentiation of autoimmune pancreatitis and pancreatic cancer 

  13. Jørgensen MT, Screening for pancreatic cancer in chronic pancreatitis: Should we do it at all and how? EUGW 1. November 2017 Barcelona

  14. Bjarnesen AP, Dahlin P, Christesen HT, Rasmussen L, Detlefsen S, Mortensen MB. Intraoperative Ultrasound Characteristics during Surgical Treatment of Congenital Hyperinsulinism: A Prospective and blinded Single-centre Analysis. European Paediatric Surgeons’ Association EUPSA 20th congress, Beograde, 12-15/6 2019

  15. Christesen H. Diazoxide Unresponsive Forms of Congenital Hyperinsulinism. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  16. Petersen H. 18F-DOPA PET/CT in diagnosing focal pancreatic hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  17. Rasmussen, A. Diffuse and atypical congenital hyperinsulinism: Urgent need for new treatment modalities. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  18. Christesen H. Feeding avoidance, overweight and malabsorption in children with congenital hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  19. Bjarnesen AP, Dahlin P, Christesen HT, Rasmussen L, Detlefsen S, Mortensen MB. Intraoperative Ultrasound Characteristics during Surgical Treatment of Congenital Hyperinsulinism: A Prospective and blinded Single-centre Analysis. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  20. AlHaidan Y. Whole exome sequencing and CRISPR/cas9 in search for new genes in congenital hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  21. Christensen LG. Whole genomic paternal uniparental disomy in congenital hyperinsulinism: A mutisyndromal disease. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  22. Larsen AR. A novel somatic gene mutation in pancreatic tissue: Loss of tumor suppression and hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  23. Drogseth TE. Glucagonoma and occult insulinoma in a girl with MEN1. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  24. El-Rifai O. Transient congenital hyperinsulinism: Genetic disease or perinatal stress? 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  25. Christesen H: Novel treatment of congenital hyperinsulinism: Liquid glucagon, insulin receptor antibodies, novel somatostatin analogues, CRISPR/Cas9 therapy. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  26. Tan M, Gene co-expression network analyses of precursor lesions in familial pancreatic cancer, EUGW Barcelona, 23/10 2019

  27. Schaffalitzky de Muckadell O, Managing Chronic Pancreatitis Endoscopically - Stenoses and Strictures, 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019
  28. Graversen M, Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in patients with peritoneal metastasis from pancreatic cancer, 1st Congress of ISSPP International Society for the Study of Pleura and Peritoneum, Singapore, 29-30/11 2019

 

Posters:

  1. Dichmann JB, Laursen MØ, Mortensen MB, Melikian M, Globa E, Detlefsen S, Rasmussen L, Petersen H, Brusgaard K, Christesen H. Intraoperative ultrasound guided curative tissue sparing pancreatic resection in focal congenital hyperinsulinism. ENDO 2018, March 17-20, Chicago, Illinois, US 
  2. Mazanti H, Christesen H. Demands, strengths and challenges in the treatment of children at The International Congenital Hyperinsulinism Center of Denmark. 3rd International Conference on Pediatric Nursing and Healthcare. September 21-22, 2018, Vancouver, Canada 

  3. Globa E, Zelinska N, Ellard S, Flanagan S, Christesen H. 20 Cases of Congenital Hyperinsulinism in Ukraine.   ESPE 57th annual meeting, Athens, 27-29/9 2018 

  4. Rasmussen AG, Melikian M, Globa E, Detlefsen S, Rasmussen L, Petersen H, Brusgaard K, Rasmussen AH, Christesen H. Forty Patients with Persistent, Non-focal Congenital Hyperinsulinism: Urgent Need for New Treatment Modalities. ESPE 57th annual meeting, Athens, 27-29/9 2018 

  5. Dichmann JB, Laursen MØ, Mortensen MB, Melikian M, Globa E, Detlefsen S, Rasmussen L, Petersen H, Brusgaard K, Christesen HT. Intraoperative ultrasound guided curative tissue sparing pancreatic resection in focal congenital hyperinsulinism. ENDO 2018, March 17-20, Chicago, Illinois, US

  6. Boonen SE, Christesen H, Bertelsen B, Borgwardt L, Dayani G, Nielsen JEK. Neonatal death expands the phenotype of megalencephaly capillary malformation syndrome with transient hypoinsulinaemic, hypoketotic hypoglycaemia due to a PIK3CA mutation. Eur. Soc. Of Human Genetics, Gothenburg, Sweden, June 15-18, 2019

  7. Gubaeva D, Melikyan M, Tiulpakov A, Brusgaard K, Christesen H. Congenital hyperinsulinism due to GCK gene mutations in the Russian cohort. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  8. Christesen HT, Christensen L, Löfgren Å, Brøndum-Nielsen K, Svensson J, Brusgaard K, Samuelsson S, Elfving M, Jonson T, Grønskov K, Rasmussen L, Backman T, Hansen LK, Larsen AR, Petersen H, Detlefsen.  Tissue variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromic congenital hyperinsulinism. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  9. Boonen SE, Christesen H, Bertelsen B, Borgwardt L, Dayani G, Nielsen JEK. Neonatal death expands the phenotype of megalencephaly capillary malformation syndrome with transient hypoinsulinaemic, hypoketotic hypoglycaemia due to a PIK3CA mutation. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  10. Riis, SST, Jørgensen MH, Rasmussen KF, Husby S, Hasselby JP, Borgwardt L, Brusgaard K, Fagerberg C, Christesen HT. A novel pseudo-syndrome of transient congenital hyperinsulinism and conjugated hyperbilirubinaemia due to Rhesus D prophylaxis failure. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  11. Bjarnesen AP, Dahlin P, Christesen HT, Rasmussen L, Detlefsen S, Mortensen MB. Intraoperative Ultrasound Characteristics during Surgical Treatment of Congenital Hyperinsulinism: A Prospective and blinded Single-centre Analysis. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  12. Andersen KØ, Brusgaard K, Detlefsen S, Christesen HT. Somatic Mutations in Pancreatic Tumors in three Siblings with Multiple Endocrine Neoplasia Type 1. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  13. Tan, M., Schaffalitzky, O. B., & Joergensen, M. T.  Gene co-expression network analysis of precursor lesions in familial pancreatic cancer. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  14. Tan, M., Schaffalitzky, O. B., & Joergensen, M. T. Gene co-expression network analysis of precursor lesions in familial pancreatic cancer. Genomic Medicine 2019 Nordic, Kennedy Centret, Copenhagen, Denmark, 13-14/11-2019


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