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News

Sep 17, 2019
Category: General
Posted by: jettebang

Info on Friday morning 

Sep 4, 2019
Category: General
Posted by: jettebang

New deadline for registration and submission of abstract is September 13th at 12 a.m.

Sep 4, 2019
Category: General
Posted by: jettebang

A beautiful morning run

Feb 5, 2019
Category: General
Posted by: jettebang

We are happy to announce that registration for First Scandinavian Baltic Pancreas Symposium, 20-21 September 2019, opens at the end of February on www.OPAC.nu

Oct 18, 2018
Category: General
Posted by: jettebang

The program for First Scandinavia Baltic Pancreas Symposium, September 2019 is now available on our website www.opac.nu


Publications

 

Peer reviewed articles:

  1. Identification of markers for quiescent pancreatic stellate cells in the normal human pancreas. Nielsen MFB, Mortensen MB, Detlefsen S. Histochem Cell Biol. 2017;148(4):359-80.
     
  2. IgG4-related disease. Histologic diagnosis and differential diagnosis [in German]. Detlefsen S. [Pathologe, in press]

  3. Value of anti-PBP, anti-CA-II, IgG4 and other serological markers for the differentiation of autoimmune pancreatitis and pancreatic cancer. Detlefsen S, de Vos JD, Tanassi JT, Heegaard NHH, Fristrup CW, Schaffalitzky de Muckadell OB. Medicine (Baltimore), 2018; Aug;97(31):e11641. doi: 10.1097/MD.0000000000011641

  4. Synchronous pancreatic serous cystic neoplasm and duodenal neuroendocrine tumor: case report and review of the literature. Madelung AB, Detlefsen S

  5. Peritoneal metastasis from pancreatic cancer treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Graversen M, Detlefsen S, Bjerregaard JK, Pfeiffer P, Mortensen MB. Clin Exp Metastasis. 2017 May 17. doi: 10.1007/s10585-017-9849-7

  6. Prospective evaluation of EUS-guided fine needle biopsy in pancreatic mass lesions. Larsen MH, Fristrup CW, Detlefsen S and Mortensen MB. Endoscopy International Open 2018; 6(2):E242-8. 

  7. Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations. Huang L, Jansen L, Balavarca Y, Molina-Montes E, Babaei M, van der Geest L, Lemmens V, Van Eycken L, De Schutter H, Johannesen TB, Fristrup CW, Mortensen MB, Primic-Ċ½akelj M, Zadnik V, Becker N, Hackert T, Mägi M, Cassetti T, Sassatelli R, Grützmann R, Merkel S, Gonçalves AF, Bento MJ, Hegyi P, Lakatos G, Szentesi A, Moreau M, van de Velde T, Broeks A, Sant M, Minicozzi P, Mazzaferro V, Real FX, Carrato A, Molero X, Besselink MG, Malats N, Büchler MW, Schrotz-King P, Brenner H. Gut. 2017 Nov 20. pii: gutjnl-2017-314828. doi: 10.1136/

  8. Prospective, single-center implementation and response evaluation of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for peritoneal metastasis. Graversen M, Detlefsen S, Bjerregaard JK, Fristrup C, Pferiffer P, Mortensen MB. Therapeutic Advances in Medical Oncology 2018 /DOI: 10.1177/1758835918777036

  9. The impact of endoscopic ultrasound-guided fine-needle aspiration of lymph nodes on subsequent positron emission tomography/computed tomography imaging: a prospective study. Ole Steen Bjerring, Søren Hess, Claus Wilki Fristrup, Poul Flemming Høilund-Carlsen, Michael Bau Mortensen. Endoscopy 2019;51(02): 165-8.

  10. 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT scans as diagnostic tools in focal congenital hyperinsulinism: a blinded evaluation. Christiansen CD, Petersen H, Nielsen AL, Detlefsen S, Brusgaard K, Rasmussen L, Melikyan M, Ekström K, Globa E, Rasmussen AH, Hovendal C, Christesen HT. Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):250-261.

  11. A Multicentre Experience with Long-Acting Somatostatin Analogues in Patients with Congenital Hyperinsulinism. Van der Steen I, van Albada ME, Mohnike K, Christesen HT, Stuart AJ, van der Linde A, Banerjee I, Boot AM. Horm Res 2018;89(2):82-89.
     
  12. Intraoperative ultrasound: A tool to support tissue-sparing curative pancreatic resection in focal hyperinsulinism. Bendix J, Laursen MØ, Mortensen MB, Melikian M, Globa E, Detlefsen S, Rasmussen L, Brusgaard K, Christesen HT. Frontiers Endocrinol, E-pub 22/8 2018, https://doi.org/10.3389/fendo.2018.00478
     
  13. Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations. Nielsen MFB, Mortensen MB, Detlefsen S. World J Gastroenterol. 2018 Nov 7;24(41):4663-4678.

  14. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) as an outpatient procedure. Graversen M, Lundell L, Fristrup C, Pfeiffer P, Mortensen MB. Pleura and Peritoneum 2018;3(4): 20180128.

  15. Reproducibility of the Peritoneal Regression Grading Score (PRGS) for assessment of response to therapy in peritoneal metastasis. Wiebke Solass, Christine Sempoux, Norman Carr, Frédéric Bibeau, Daniel Neureiter, Tarkan Jäger, Tina Di Caterino, Christophe Brunel, Eckhard Klieser, Claus Fristrup, Michael Bau Mortensen, Sönke Detlefsen. Histopathology 2019 (in press)

  16. Multicentre Study of Multidisciplinary Team Assessment of Pancreatic Cancer Resectability and Treatment Allocation. J. Kirkegård, E.K.Aahlin, M.Al-Saiddi, S.O.Bratlie, M.Coolsen, R.J. de Haas, M den Dulk, C.Fristrup, E.M. Harrison, M.B. Mortensen, M.W. Nijkamp, J. Persson, J.A. Søreide, S.J. Wigmore, T. Wik, F.V. Mortensen. Br J Surg 2019; https://doi.org/1.1002/bjs.11093 

  17. Tissue variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromic congenital hyperinsulinism. Christesen HT, Christensen L, Löfgren Å, Brøndum-Nielsen K, Svensson J, Brusgaard K, Samuelsson S, Elfving M, Jonson T, Grønskov K, Rasmussen L, Backman T, Hansen LK, Larsen AR, Petersen H, Detlefsen. Eur J Med Genet. 2019 Feb 20. pii: S1769-7212(18)30932-7 [E-pub ahead of print]

  18. The effect of postoperative gemcitabine on overall survival in patients with resected pancreatic cancer: A nationwide population-based Danish register study. Louise Skau Rasmussen, Benny Vittrup, Morten Ladekarl, Per Pfeiffer, Mette Karen Yilmaz, Laurids Østergaard Poulsen, Kell Østerlind, Carsten Palnæs Hansen, Michael Bau Mortensen, Frank Viborg Mortensen, Mogens Sall, Sönke Detlefsen, Martin Bøgsted & Claus Wilki Fristrup. ACTA ONCOLOGICA 2019, doi.org/10.1080/0284186X.2019.1581374

  19. The added value of endosonography and PET/CT to the traditional follow up strategy in patients radically resected for cancer either of the gastro-esophageal junction (GEJ), stomach or pancreas – EUFURO - a phase 2 randomized clinical trial. Ole S. Bjerring, Claus W. Fristrup, Per Pfeiffer, Lars Lundell, Michael B. Mortensen. Br J Surg 2019 (in press)

  20. Waiting time to surgery for pancreatic cancer does not affect survival: A nationwide population-based cohort study. Jakob Kirkegård, Frank Viborg Mortensen, Carsten Palnæs Hansen, Michael Bau Mortensen, Mogens Sall, Henriette Engberg, Claus Fristrup. EJSO 2019 (in press).

  21. Mutational profilling and immunohistochemical analyses of a surgical series of ampullary carcinomas. Harthimmer MR, Stolborg U, Pfeiffer P, Mortensen MB, Fristrup C, Detlefsen S. J Clin Pathol, Epub ahead of print

  22. Squamous cell carcinoma of the common bile duct: A case report with genomic profiling. Knudsen KN, Mortensen MB, Detlefsen S. Pathol Int, Epub ahead of print

  23. Tissue Variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromal congenital hyperinsulinism. Christesen HT, Christensen LG, Löfgren AM, Brøndum-Nielsen K, Svensson J, Brusgaard K, Samuelsson S, Elfving M, Jonson T, Grønskov K, Rasmussen L, Backman T, Hansen LK, Larsen AR, Petersen H, Detlefsen S. Eur J Med Genet 2019 Feb 20. Pii: S1769-7212(18)30932-7 doi: 10.1016/j.ejmg2019.02.004. Epub ahead of print

  24. IgG4 related sclerosing cholangitis involving intrahepatic bile ducts diagnosed with liver biopsy. Thinesen MT, Schaffalitzky de Muckadell OB, Detlefsen S. Case Reports in Pathology 2018, article 2309203

  25. Value of antiplasminogen binding peptide, anticorbon anhydrase, innunoglobulin G4, and other serological markers in the differentiation of autoimmune pancreatitis and pancreatic cancer. Detlefsen S, de Vos JD, Tanassi J, et at. Medicine 2018:97(31):article 11641.

 

Other articles:

  1. Graversen M, Mortensen MB. PRESSURIZED INTRAPERITONEAL AEROSOL CHEMOTHERAPY (PIPAC): A new treatment modality in patients with peritoneal metastases from pancreatic cancer? Pancreatic cancer, Nordic Newsletter, no. 4, 2017. (Invited publication) 


Oral Presentations:

  1. Martin Graversen, Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) som palliativ behandling ved pancreascancer med peritoneal karcinose. Dansk Pancreas Forum 2017, København
     
  2. Martin Graversen, Peritoneal metastases from pancreatic cancer treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Scandinavian HPB meeting, Lund, Sverige 2017.

  3. Christesen H. Hyperinsulinisme hos børn. Annual meeting, the Danish Society of Radiology, the Danish Society of Clinical Physiology and Nuclear Medicine, The Danish Society of Ultrasound and Radiographer, 25/1 2018, Odense.

  4. Christesen HT. Diagnostic performance of 18F-DOPA PET/CT and 68GA-DOTANOC PET/CT scan on focal vs. non-focal type of congential hyperinsulinism. Congenital Hyperinsulinism Symposia, Children’s Hospital of Philadelphia, 14/4 2016

  5. Maria Melikyan, Sergey Makarov, Larisa Gurevich, Youriy Sokolov, Henrik Christesen. Pancreatic insulinomas in childhood: clinical, morphological and genetic characteristics of 16 children. 10th International Meeting of Pediatric Endocrinology, Washington D.C., US, 14-17/9 2017 

  6. Christesen H, Congenital Hyperinsulinism. Etiology, pathophysiology, clinical presentation and therapy. Symposium: Team approach in the medical care for children and adults with hyperinsulinism. Christesen H. , Almazov National Medical research Centre, St. Petersburg, Russia, March 5, 20181  
     
  7. Detlefsen S, Histopathology in Congenital Hyperinsulinism. Symposium: Team approach in the medical care for children and adults with hyperinsulinism. Almazov National Medical research Centre, St. Petersburg, Russia, March 5, 20181
      
  8. Brusgaard K, Exome sequencing in patients with early childhood-diabetes or hyperinsulinemic hypoglycemia reveals novel genetic causes. 61. Deutscher Kongress für Endokrinologie, 14.03.2018 – 16.03.2018 · Bonn.  

  9. Graversen, M, The PIPAC Procedure. Peritoneal Metastazlarin Tedavisinde Basincli Intraperitoneal Aerosol Kemoterapi (PIPAC). Konferansimiza Davetlisiniz. (PIPAC Meeting at Anadolu Hospital Centre, Istanbul, Turkey.) 

  10. Graversen, M, Publications and the Danish Experience. Peritoneal Metastazlarin Tedavisinde Basincli Intraperitoneal Aerosol Kemoterapi (PIPAC). Konferansimiza Davetlisiniz. (PIPAC Meeting at Anadolu Hospital Centre, Istanbul, Turkey.) 

  11. Jørgensen MT, Mortensen MB., Clinical dillemmas in chronic pancreatitis. Dansk Pancreas Forum 2018 Meeting. Copenhagen 16.03.18 

  12. Hedegaard Jensen, G., Mortensen, M. B., Detlefsen, S., Value of the immunohistochemical panel IMP3, pVHL, maspin, S100P and Ki67 for the differentiation of autoimmune pancreatitis and pancreatic cancer 

  13. Jørgensen MT, Screening for pancreatic cancer in chronic pancreatitis: Should we do it at all and how? EUGW 1. November 2017 Barcelona

  14. Bjarnesen AP, Dahlin P, Christesen HT, Rasmussen L, Detlefsen S, Mortensen MB. Intraoperative Ultrasound Characteristics during Surgical Treatment of Congenital Hyperinsulinism: A Prospective and blinded Single-centre Analysis. European Paediatric Surgeons’ Association EUPSA 20th congress, Beograde, 12-15/6 2019

  15. Christesen H. Diazoxide Unresponsive Forms of Congenital Hyperinsulinism. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  16. Petersen H. 18F-DOPA PET/CT in diagnosing focal pancreatic hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  17. Rasmussen, A. Diffuse and atypical congenital hyperinsulinism: Urgent need for new treatment modalities. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  18. Christesen H. Feeding avoidance, overweight and malabsorption in children with congenital hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  19. Bjarnesen AP, Dahlin P, Christesen HT, Rasmussen L, Detlefsen S, Mortensen MB. Intraoperative Ultrasound Characteristics during Surgical Treatment of Congenital Hyperinsulinism: A Prospective and blinded Single-centre Analysis. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  20. AlHaidan Y. Whole exome sequencing and CRISPR/cas9 in search for new genes in congenital hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  21. Christensen LG. Whole genomic paternal uniparental disomy in congenital hyperinsulinism: A mutisyndromal disease. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  22. Larsen AR. A novel somatic gene mutation in pancreatic tissue: Loss of tumor suppression and hyperinsulinism. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  23. Drogseth TE. Glucagonoma and occult insulinoma in a girl with MEN1. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  24. El-Rifai O. Transient congenital hyperinsulinism: Genetic disease or perinatal stress? 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  25. Christesen H: Novel treatment of congenital hyperinsulinism: Liquid glucagon, insulin receptor antibodies, novel somatostatin analogues, CRISPR/Cas9 therapy. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019

  26. Tan M, Gene co-expression network analyses of precursor lesions in familial pancreatic cancer, EUGW Barcelona, 23/10 2019

Posters:

  1. Intraoperative ultrasound guided curative tissue sparing pancreatic resection in focal congenital hyperinsulinism. Dichmann JB, Laursen MØ, Mortensen MB, Melikian M, Globa E, Detlefsen S, Rasmussen L, Petersen H, Brusgaard K, Christesen HT. ENDO 2018, March 17-20, Chicago, Illinois, US 

  2. Demands, strengths and challenges in the treatment of children at The International Congenital Hyperinsulinism Center of Denmark.  Mazanti H, Christesen HT. 3rd International Conference on Pediatric Nursing and Healthcare. September 21-22, 2018, Vancouver, Canada 

  3. 20 Cases of Congenital Hyperinsulinism in Ukraine.  Evgenia Globa, Nataliya Zelinska, Sian Ellard, Sarah Flanagan, Henrik Christesen. ESPE 57th annual meeting, Athens, 27-29/9 2018 

  4. Forty Patients with Persistent, Non-focal Congenital Hyperinsulinism: Urgent Need for New Treatment Modalities.  Amalie Greve Rasmussen, Maria Melikian, Evgenia Globa, Sonke Detlefsen, Lars Rasmussen, Henrik Petersen, Klaus Brusgaard, Annett Helleskov Rasmussen, Henrik Christesen. ESPE 57th annual meeting, Athens, 27-29/9 2018 

  5. Dichmann JB, Laursen MØ, Mortensen MB, Melikian M, Globa E, Detlefsen S, Rasmussen L, Petersen H, Brusgaard K, Christesen HT. Intraoperative ultrasound guided curative tissue sparing pancreatic resection in focal congenital hyperinsulinism. ENDO 2018, March 17-20, Chicago, Illinois, US

  6. Boonen SE, Christesen H, Bertelsen B, Borgwardt L, Dayani G, Nielsen JEK. Neonatal death expands the phenotype of megalencephaly capillary malformation syndrome with transient hypoinsulinaemic, hypoketotic hypoglycaemia due to a PIK3CA mutation. Eur. Soc. Of Human Genetics, Gothenburg, Sweden, June 15-18, 2019

  7. Diliara Gubaeva, Maria Melikyan, Anatoly Tiulpakov, Klaus Brusgaard, Henrik Christesen. Congenital hyperinsulinism due to GCK gene mutations in the Russian cohort. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  8. Christesen HT, Christensen L, Löfgren Å, Brøndum-Nielsen K, Svensson J, Brusgaard K, Samuelsson S, Elfving M, Jonson T, Grønskov K, Rasmussen L, Backman T, Hansen LK, Larsen AR, Petersen H, Detlefsen.  Tissue variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromic congenital hyperinsulinism. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  9. Boonen SE, Christesen H, Bertelsen B, Borgwardt L, Dayani G, Nielsen JEK. Neonatal death expands the phenotype of megalencephaly capillary malformation syndrome with transient hypoinsulinaemic, hypoketotic hypoglycaemia due to a PIK3CA mutation. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  10. Riis, SST, Jørgensen MH, Rasmussen KF, Husby S, Hasselby JP, Borgwardt L, Brusgaard K, Fagerberg C, Christesen HT. A novel pseudo-syndrome of transient congenital hyperinsulinism and conjugated hyperbilirubinaemia due to Rhesus D prophylaxis failure. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  11. Bjarnesen AP, Dahlin P, Christesen HT, Rasmussen L, Detlefsen S, Mortensen MB. Intraoperative Ultrasound Characteristics during Surgical Treatment of Congenital Hyperinsulinism: A Prospective and blinded Single-centre Analysis. Updates in Diagnosis and Management of hyperinsulinism and neonatal hypoglycemia conference, Philadelphia, PE, USA, 5-6/9 2019.

  12. Andersen KØ, Brusgaard K, Detlefsen S, Christesen HT. Somatic Mutations in Pancreatic Tumors in three Siblings with Multiple Endocrine Neoplasia Type 1. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolidng, Denmark, 20-21/9 2019
  13. Tan, M., Schaffalitzky, O. B., & Joergensen, M. T.  Gene co-expression network analysis of precursor lesions in familial pancreatic cancer. 1st Scandinavian Baltic Pancreas Symposium, Odense Pancreas Centre (OPAC), Kolding, Denmark, 20-21/9 2019 

  14. Tan, M., Schaffalitzky, O. B., & Joergensen, M. T. Gene co-expression network analysis of precursor lesions in familial pancreatic cancer. Genomic Medicine 2019 Nordic, Kennedy Centret, Copenhagen, Denmark, 13-14/11-2019

 



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